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Preliminary Results on the Effects of CD40/CD40L Interactions and SAC-induction on IFN-γ Expression in Human Schistosomiasis Silvia ML Montenegro; Frederico GC Abath; Ana LC Domingues; Wlademir Melo; Clarice NL de Morais; Eridan M Coutinho; Siddhartha Mahanty & Thomas Wynn Abstract In this communication the authors analyzed the pattern of expression of IFN-γ as a surrogate type 1 response in different clinical forms of schistosomiasis in response to stimulation involving T-cell dependent and T-cell independent pathways, to investigate which pathways were functional in human schistosomiasis, and to further characterize the nature of Th1 response impairment in this parasitic disease. Keywords Schistosoma mansoni, CD40/CD40 ligand, human schistosomiasis, IFN-γ

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