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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 7, 2001, pp. 997-999
Bioline Code: oc01193
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 7, 2001, pp. 997-999

 en SHORT COMMUNICATION - Dissociation between Vasodilation and Leishmania check for this species in other resources Infection-enhancing Effects of Sand Fly Saliva and Maxadilan
Fábio Castro-Sousa; Moacir Paranhos-Silva; Ítalo Sherlock; Mariza S Paixão; Lain C Pontes-de-Carvalho & Washington LC dos-Santos


In this study, the ability of maxadilan and Lutzomyia longipalpis check for this species in other resources salivary gland lysate to enhance the infection of CBA mice by Leishmania major check for this species in other resources and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania check for this species in other resources alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments.

Lutzomyia longipalpis saliva, maxadilan, Leishmania major, Leishmania braziliensis, vasodilation

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