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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 96, No. 7, 2001, pp. 1001-1003
Bioline Code: oc01194
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 96, No. 7, 2001, pp. 1001-1003

 en SHORT COMMUNICATION - Worm Load and Septal Fibrosis of the Liver in Capillaria hepatica check for this species in other resources -infected Rats
Roseli Fernandes Oliveira & Zilton A Andrade

Abstract

Inocula, varying from 15 to 1,000 embryonated Capillaria hepatica check for this species in other resources eggs, were administered to young adult rats by gastric tube, in an attempt to investigate the influence of worm load in the production of septal fibrosis of the liver. Low doses of 15, 30 or 50 eggs were sufficient to produce septal fibrosis, but it appeared with variable degrees of intensity and always with focal distribution. Septal fibrosis became diffuse, progressive with time, and already well developed 40 days after infection, when 100 eggs or more were administered. However, higher inocula (200, 500 and 1,000 eggs) did not intensify septal fibrosis, although the number of parasitic focal lesions proportionally augmented.

Keywords
Capillaria hepatica, septal hepatic fibrosis, worm load

 
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