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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 97, No. 4, 2002, pp. 523-526
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Bioline Code: oc02099
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 4, 2002, pp. 523-526
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SHORT COMMUNICATION - Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design
ML Guimarães; AS Moreira & MG Morgado
Abstract
Most of the Brazilian HIV-1 samples have been characterized
based on the structural genes (env, gag and pol) and no data concerning
the variability of the accessory genes such as
nef
have been available so far. Considering the role of the
nef
on virus biology and the inclusion of this region in some HIV/AIDS vaccine
products under testing, the purpose of this study was to document the genetic
diversity of the
nef
gene in third-four HIV-1 Brazilian samples previously subtyped based on
the env C2-V3 region. Although only few non-subtype B samples have already
been analyzed so far, the cytotoxic Tlymphocyte epitopes encoded in this
region were relatively conserved among the subtypes, with some amino acid
signatures mainly in the subtype C samples. Considering the increasing of
the non-B HIV-1 subtypes worldwide, in special the subtype C, more data
should be generated concerning the genetic and antigenic variability of
these subtypes, as well as the study of the impact of such polymorphism
in HIV/AIDS vaccine design and testing.
Keywords
nef gene - HIV-1 polymorphism - HIV/AIDS vaccine - B cell and CTL nef epitopes
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