Trypanosoma cruzi check for this species in other resources - nitroarylidene - malononitriles - in vitro assays - cytotoxicity assays - in vivo experiments"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 4, 2002, pp. 553-557
Bioline Code: oc02105
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 4, 2002, pp. 553-557

 en In Vitro and in Vivo Anti- Trypanosoma cruzi check for this species in other resources Activity of a Novel Nitro-derivative
Susana Muelas-Serrano; Ana Le-Senne; Carlos Fernández-Portillo; Juan José Nogal; Carmen Ochoa* & Alicia Gómez-Barrio

Abstract

Nitroarylidenemalononitriles and their cyanoacetamide derivatives with remarkable anti-epimastigote properties, were synthesized attempting to obtain new 3,5-diamino-4-(5'-nitroarylidene)-4H-thiadiazine 1,1-dioxide derivatives, which in previous reports had shown anti- Trypanosoma cruzi check for this species in other resources activity. Tests to evaluate the cytotoxicity of compounds were performed on J774 macrophages. 5-nitro-2-thienyl-malononitrile (5NO 2 TM), was the only product which maintained a high anti-epimastigote activity at concentrations in which it was no longer cytotoxic, thus it was assayed against intracellular amastigotes. Its anti-amastigote activity was similar to that of nifurtimox. Afterwards in vivo toxicity and anti-chagasic activity were determined. A reduction in parasitemia was observed.

Keywords
Trypanosoma cruzi check for this species in other resources - nitroarylidene - malononitriles - in vitro assays - cytotoxicity assays - in vivo experiments

 
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