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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 97, No. 5, 2002, pp. 643-644
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Bioline Code: oc02123
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 5, 2002, pp. 643-644
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SHORT COMMUNICATION - Prevalence of Hepatitis C Virus Infection among Hemophiliacs in Central Brazil
Adriana P Barbosa; Regina MB Martins; Sheila A Teles; Simonne A Silva; Jaqueline M Oliveira & Clara FT Yoshida
Abstract
In order to investigate the hepatitis C virus (HCV) infection
prevalence and risk factors in hemophiliacs in Central Brazil, 90 patients
were interviewed and serum samples tested for HCV RNA and anti-HCV antibodies.
An overall prevalence of 63.3% (CI 95%: 53.0-72.7) was found. Multivariate
analysis of risk factors showed that number of blood transfusions was significantly
associated with this infection. Most hemophiliacs received locally produced
cryoprecipitate. All infected patients were transfused before the screening
of blood units for anti-HCV. However, hemophiliacs who received exclusively
screened cryoprecipitate were HCV negative. It confirms the expected decline
in transfusion-acquired hepatitis C.
Keywords
hepatitis C - hemophilia - prevalence - Central Brazil
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