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Hantavirus Pulmonary Syndrome in Uberaba, Minas Gerais, Brazil Mario León Silva-Vergara; José Carlos Costa Júnior; Cristina Hueb Barata; Vítor Guilherme Maluf Curi; Carlos Giovanni Tiveron Júnior & Alan César Teixeira Abstract This report describes the epidemiological and clinical-evolutive characteristics of eight patients with hantavirus pulmonary syndrome (HPS) in Uberaba, Minas Gerais, Brazil. A positive history of contact with rodents was present in 100% of the cases. The time between the onset of symptoms and hospital care was, on average, 3.6 days. All patients showed clinical and laboratory findings suggestive of HPS. Elevated urea and creatinine levels were observed in 6 (75%) cases, PO 2 was < 60 mmHg in 100% of the cases, and a chest X-ray demonstrated a bilateral interstitial-alveolar infiltrate. The diagnosis was confirmed by the detection of IgM antibodies against Sin Nombre virus by ELISA. Three patients died as a direct consequence of HPS. Keywords hantavirus - hantavirus pulmonary syndrome/HPS - Sin Nombre virus - Minas Gerais - Brazil

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