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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 6, 2002, pp. 887-892
Bioline Code: oc02170
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 6, 2002, pp. 887-892

 en Susceptibility of Spiny Rats (Proechimys semispinosus) to Leishmania (Viannia) panamensis check for this species in other resources and Leishmania ( Leishmania) chagasi check for this species in other resources
BL Travi; LT Arteaga; AP León & GH Adler

Abstract

The role of Proechimys semispinosus check for this species in other resources as reservoir of Leishmania (Viannia) panamensis check for this species in other resources on the Colombian Pacific coast was experimentally evaluated. The susceptibility to L. chagasi also was assessed to determine the utility of this rodent as a model for studying reservoir characteristics in the laboratory. Wild-caught animals were screened for natural trypanosomatid infections, and negative individuals were inoculated intradermally (ID) in the snout or feet with 107 promastigotes of L. panamensis. L. chagasi was inoculated intracardially (107 promastigotes) or ID in the ear (108 promastigotes). PCR-hybridization showed that 15% of 33 spiny rats were naturally infected with L. Viannia sp. Animals experimentally infected with L. panamensis developed non-ulcerated lesions that disappeared by the 7th week post-infection (p.i.) and became more resistant upon reinfection. Infectivity to sand flies was low (1/20-1/48 infected/fed flies) and transient, and both culture and PCR-hybridization showed that L. panamensis was cleared by the 13th week p.i. Animals inoculated with L. chagasi became subclinically infected and were non-infective to sand flies. Transient infectivity to vectors of spiny rats infected with L. panamensis , combined with population characteristics, e.g., abundance, exploitation of degraded habitats and high reproductive rates, could make them epidemiologically suitable reservoirs.

Keywords
spiny rats - Leishmania check for this species in other resources - reservoir - experimental infection

 
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