Schistosoma mansoni check for this species in other resources - Schistosoma haematobium check for this species in other resources - antibody - age-infection experience - treatment"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. s1, 2002, pp. 173-180
Bioline Code: oc02209
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. s1, 2002, pp. 173-180

 en The Effect of Treatment on the Age-antibody Relationship in Children Infected with Schistosoma mansoni check for this species in other resources and Schistosoma haematobium check for this species in other resources
Francisca Mutapi; Takafira Mduluza & Patricia D Ndhlovu

Abstract

The effect of praziquantel treatment on the age-antibody relationship was studied in 174 children aged between 6 and 17 years from a schistosome endemic area in Zimbabwe. The children were co-infected with Schistosoma mansoni and S. haematobium with infection prevalences of 74% and 53% respectively. Antibody levels for the isotypes IgA, IgE, IgM, IgG1, IgG2, IgG3 and IgG4, directed against soluble egg antigen were measured using an indirect ELISA assay. Treatment resulted in a significant increase in levels of IgG2 and IgG3 while levels of IgA decreased significantly. In untreated children there were significant decreases in levels of IgG4. Treatment also resulted in significant alteration in the age-antibody profiles for the isotypes IgE, IgM, IgG1 and IgG2 in treated children but not in untreated children. The results are discussed in the context of factors believed to give rise to the age-antibody relationship; i.e. age-related exposure patterns, age-related development of acquired immunity, age-related hormonal changes and age-related changes in innate susceptibility to infection.

Keywords
Schistosoma mansoni check for this species in other resources - Schistosoma haematobium check for this species in other resources - antibody - age-infection experience - treatment

 
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