Trypanosoma cruzi check for this species in other resources - autochthonous antigens - Puebla - Mexico"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 7, 2002, pp. 947-952
Bioline Code: oc02216
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 7, 2002, pp. 947-952

 en High Prevalence Anti- Trypanosoma cruzi check for this species in other resources Antibodies, among Blood Donors in the State of Puebla, a Non-endemic Area of Mexico
MC Sánchez-Guillén; C Barnabé; JF Guégan; M Tibayrenc; M Velásquez-Rojas; J Martínez-Munguía; H Salgado-Rosas; E Torres-Rasgado; MI Rosas-Ramírez & R Pérez-Fuentes

Abstract

Blood transfusion is the second most common transmission route of Chagas disease in many Latin American countries. In Mexico, the prevalence of Chagas disease and impact of transfusion of Trypanosoma cruzi check for this species in other resources -contaminated blood is not clear. We determined the seropositivity to T. cruzi in a representative random sample, of 2,140 blood donors (1,423 men and 647 women, aged 19-65 years), from a non-endemic state of almost 5 millions of inhabitants by the indirect hemagglutination (IHA) and enzyme linked immunosorbent assay (ELISA) tests using one autochthonous antigen from T. cruzi parasites, which were genetically characterized like TBAR/ME/1997/RyC-V1 (T. cruzi I) isolated from a Triatoma barberi check for this species in other resources specimen collected in the same locality. The seropositivity was up to 8.5% and 9% with IHA and ELISA tests, respectively, and up to 7.7% using both tests in common. We found high seroprevalence in a non-endemic area of Mexico, comparable to endemic countries where the disease occurs, e.g. Brazil (0.7%), Bolivia (13.7%) and Argentina (3.5%). The highest values observed in samples from urban areas, associated to continuous rural emigration and the absence of control in blood donors, suggest unsuspected high risk of transmission of T. cruzi, higher than those reported for infections by blood e.g. hepatitis (0.1%) and AIDS (0.1%) in the same region.

Keywords
Chagas disease - seroprevalence - blood donors - antibodies to Trypanosoma cruzi check for this species in other resources - autochthonous antigens - Puebla - Mexico

 
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