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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 7, 2002, pp. 979-983
Bioline Code: oc02221
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 7, 2002, pp. 979-983

 en B-cell Infiltration and Frequency of Cytokine Producing Cells Differ between Localized and Disseminated Human Cutaneous Leishmaniases
MGS Vieira; F Oliveira; S Arruda; AL Bittencourt; AA Barbosa Jr; M Barral-Netto & A Barral

Abstract

Biopsies from human localized cutaneous lesions (LCL n = 7) or disseminated lesions (DL n = 8) cases were characterized according to cellular infiltration,frequency of cytokine (IFN-γ, TNF-α) or iNOS enzyme producing cells. LCL, the most usual form of the disease with usually one or two lesions, exhibits extensive tissue damage. DL is a rare form with widespread lesions throughout the body; exhibiting poor parasite containment but less tissue damage. We demonstrated that LCL lesions exhibit higher frequency of B lymphocytes and a higher intensity of IFN-γ expression. In both forms of the disease CD8+ were found in higher frequency than CD4+ T cells. Frequency of TNF-α and iNOS producing cells, as well as the frequency of CD68+ macrophages, did not differ between LCL and DL. Our findings reinforce the link between an efficient control of parasite and tissue damage, implicating higher frequency of IFN-γ producing cells, as well as its possible counteraction by infiltrated B cells and hence possible humoral immune response in situ.

Keywords
leishmaniasis - B lymphocytes - cytokines - CD8+ T cells - IFN-γ

 
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