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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 7, 2002, pp. 1033-1039
Bioline Code: oc02230
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 7, 2002, pp. 1033-1039

 en In Vitro Chloroquine Resistance Modulation Study on Fresh Isolates of Brazilian Plasmodium falciparum check for this species in other resources : Intrinsic Antimalarial Activity of Phenothiazine Drugs
Carla MS Menezes; Karin Kirchgatter; Sílvia M Di Santi; Carine Savalli; Fabiola G Monteiro; Gilberto A Paula & Elizabeth I Ferreira

Abstract

Phenothiazine drugs – fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine – were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum check for this species in other resources . Aiming to simulate therapeutic schedules, chloroquine was employed at the concentration used for sensitive falciparum malaria treatment and anti-psychotic therapeutic concentrations of the phenothiazine drugs were adopted in two-fold serial dilutions. The in vitro microtechnique for drug susceptibility was employed. Unlike earlier reported data, the phenothiazine modulating effect was not observed. However, all the drugs demonstrated intrinsic antiplasmodial activity in concentrations lower than those described in the literature. In addition, IC50 estimates have been shown to be inferior to the usual anti-psychotic therapeutic concentrations. Statistical analysis also suggested an increase in the parasitaemia rate or, even, a predominant antiparasitic effect of phenothiazine over chloroquine when used in combination.

Keywords
antimalarial - chloroquine - multidrug resistance - phenothiazines - modulating agents - chemosensitizer agents

 
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