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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 97, No. 8, 2002, pp. 1221-1223
Bioline Code: oc02261
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 97, No. 8, 2002, pp. 1221-1223

 en Effects of Chloroquine and Sulfadoxine/Pyrimethamine on Gametocytes in Patients with Uncomplicated Plasmodium falciparum check for this species in other resources Malaria in Colombia
Lyda Osorio; Beatriz E Ferro & Carmen M Castillo

Abstract

The effect of antimalarials on gametocytes can influence transmission and the spread of drug resistance. In order to further understand this relationship, we determined the proportion of gametocyte carriers over time post-treatment in patients with uncomplicated Plasmodium falciparum check for this species in other resources malaria who were treated with either chloroquine (CQ) or sulfadoxine/pyrimethamine (SP). The overall proportion of gametocyte carriers was high (85%) and not statistically significantly different between the CQ and SP treatment groups. However, an increased risk of carrying gametocytes on day 14 of follow up (1.26 95% CI 1.10-1.45) was found among patients having therapeutic failure to CQ compared with patients having an adequate therapeutic response. This finding confirms and extends reports of increased risk of gametocytaemia among CQ resistant P. falciparum.

Keywords
Plasmodium falciparum check for this species in other resources - gametocytes - antimalarial drugs - malaria - Colombia

 
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