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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 3, 2003, pp. 331-334
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Bioline Code: oc03077
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 3, 2003, pp. 331-334
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SHORT COMMUNICATION - Comparative Immunological Recognition of Proteins from New Guinea "C" Dengue Virus Type 2 Prototype and from a Dengue Virus Type 2 Strain Isolated in the State of Rio de Janeiro, Brazil
Luzia M de C Côrtes; Ortrud M Barth; Josery R Pantoja & Carlos R Alves
Abstract
The protein profiles of the New Guinea "C" dengue virus type 2 (DENV-2)prototype and those of a Brazilian DENV-2 isolated in the State of Rio de Janeiro in 1995 were compared. SDS-PAGE analysis showed that the virus from Rio de Janeiro expresses NS5 (93.0 kDa), NS3 (66.8 kDa) E (62.4 kDa) and NS1 (41.2 kDa) proteins differently from the New Guinea "C" virus. The immunoblot revealed specificity and antigenicity for the NS3 protein from DENV-2 Rio de Janeiro mainly in primary infections, convalescent cases, and in secondary infections in both cases and only antigenicity for E and NS1 proteins for both viruses in primary and secondary infections.
Keywords
Flavivirus  - dengue virus type 2 proteins - antigenicity - Rio de Janeiro - Brazil
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Alternative site location: http://memorias.ioc.fiocruz.br
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