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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 3, 2003, pp. 407-411
Bioline Code: oc03091
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 3, 2003, pp. 407-411

 en Increased Plasma Levels of Tumor Necrosis Factor-α in Asymptomatic/"Indeterminate" and Chagas Disease Cardiomyopathy Patients
Renata Cristina Ferreira; Barbara M Ianni; Lucia CJ Abel; Paula Buck; Charles Mady; Jorge Kalil & Edecio Cunha-Neto

Abstract

We compared plasma tumor necrosis factor-α (TNF-α) levels among asymptomatic/"indeterminate" Chagas disease patients (ASY) and patients across the clinical spectrum of chronic Chagas disease cardiomyopathy (CCC). Idiopathic dilated cardiomyopathy (DCM) patients and normal controls (NC) were included as controls. ASY Chagas disease patients had significantly higher plasma TNF-α levels than NC. TNF-α levels among severe CCC patients with significant left ventricular (LV) dysfunction were similar to those of DCM patients, showing average 2-fold higher levels than CCC patients without LV dysfunction and ASY patients, and 8-fold higher levels than NC. In Chagas disease, chronic TNF-α production prior to heart failure may play a role in CCC progression.

Keywords
Chagas disease cardiomyopathy - tumor necrosis factor-alpha - Trypanosoma cruzi

 
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