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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 4, 2003, pp. 523-528
Bioline Code: oc03114
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 4, 2003, pp. 523-528

 en Genitourinary Changes in Hamsters Infected and Reinfected with Trypanosoma cruzi check for this species in other resources
Marlene Cabrine-Santos; Vitorino Modesto dos Santos; Marcus Aurelho de Lima; Marta Elena Araújo de Abreu; Eliane Lages-Silva & Luís Eduardo Ramírez

Abstract

Authors describe genitourinary changes in male hamsters infected and reinfected with Trypanosoma cruzi check for this species in other resources . Changes in genital organs have been described in human and in experimental chagasic infection. Genital dysfunctions in chronic chagasic patients affect ejaculation, libido and sexual potency, and testis biopsies may show arrested maturation of germ cells, oligozoospermia and azoospermia. Sixty-five male hamsters were inoculated and reinoculated with 2x103 trypomastigotes of T. cruzi VIC strain, and 22 non-infected animals constituted the control group. Animals were necropsied and fragments from testis, epididymis, seminal vesicle and bladder were collected and stained with hematoxylin-eosin. Peroxidase anti-peroxidase procedure was utilized to detect tissue parasitism. T. cruzi nests were found in testis, epididymis and seminal vesicle of these hamsters. Such parasitism plays a role in the origin of genital lesions observed in humans and laboratory animals during chronic chagasic infection.

Keywords
hamsters - Trypanosoma cruzi check for this species in other resources - reinfection - testis - Chagas disease

 
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