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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 4, 2003, pp. 549-552
Bioline Code: oc03119
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 4, 2003, pp. 549-552

 en Antibacterial Xanthones from Kielmeyera variabilis check for this species in other resources Mart. (Clusiaceae)
Lucimar Pinheiro; Celso Vataru Nakamura; Benedito Prado Dias Filho; Antonio Gilberto Ferreira; Maria Claudia Marx Young & Diógenes Aparicio Garcia Cortez

Abstract

The bioassay-guided fractionation of stems from Kielmeyera variabilis check for this species in other resources , traditionally used in Brazilian folk medicine, yielded assiguxanthone-B (1), kielcorin (4), 2,5-dihydroxybenzoic acid (3), and a mixture of xanthones containing assiguxanthone-B (1) and 1,3,5,6-tetrahydroxy-2-prenylxanthone (2) (1:1 w/w). The xanthone mixture inhibited Staphylococcus aureus check for this species in other resources and Bacillus subtilis check for this species in other resources at a concentration of 6.25 μg/ml. When tested alone, the minimal inhibitory concentration of assiguxanthone-B was 25 μg/ml against B. subtilis. Kielcorin and 2,5-dihydroxybenzoic acid were inactive against both strains. None of the fractions was active against Escherichia coli or Pseudomonas aeruginosa. Viable cells of S. aureus were reduced by a 1-3 log CFU/ml within 12 h after exposure of one to eight times the MIC of the xanthone mixture. It is not known whether the tetrahydroxy-2-prenylxanthone or other components of the xanthone mixture are responsible for the main antibacterial activity or whether additive or synergistic action is involved

Keywords
Kielmeyera variabilis - Clusiaceae - xanthones - antibacterial activity

 
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