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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 5, 2003, pp. 605-610
Bioline Code: oc03128
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 5, 2003, pp. 605-610

 en Electrocardiographic Findings in Mexican Chagasic Subjects Living in High and Low Endemic Regions of Trypanosoma cruzi check for this species in other resources Infection
Francisca Sosa-Jurado; Miguel Mazariego-Aranda; Nidia Hernández-Becerril; Verónica Garza Murillo; Manuel Cárdenas; Pedro A Reyes; Kenji Hirayama & Victor M Monteón

Abstract

In México the first human chronic chagasic case was recognized in 1940. In spite of an increasing number of cases detected since that time, Chagas disease in México has been poorly documented. In the present work we studied 617 volunteers subjects living in high and low endemic regions of Trypanosoma cruzi check for this species in other resources infection with seroprevalence of 22% and 4% respectively. Hemoculture performed in those seropositive subjects failed to demonstrate circulating parasites, however polymerase chain reaction identified up to 60% of them as positives. A higher level of anti-T. cruzi antibodies was observed in seropositive residents in high endemic region, in spite of similar parasite persistence (p < 0.05). On standard 12 leads electrocardiogram (ECG) 20% to 22% seropositive individuals from either region showed right bundle branch block or ventricular extrasystoles which were more prevalent in seropositive than in seronegative individuals (p < 0.05). In conclusion, the frequency or type of ECG abnormality was influenced by serologic status but not by endemicity or parasite persistence. Furthermore, Mexican indeterminate patients have a similar ECG pattern to those reported in South America.

Keywords
Chagas disease - Trypanosoma cruzi check for this species in other resources - electrocardiogram alterations - seroprevalence - polymerase chain reaction

 
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