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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 5, 2003, pp. 679-686
Bioline Code: oc03140
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 5, 2003, pp. 679-686

 en Severe Anemia Affects Both Splenectomized and Non-splenectomized Plasmodium falciparum check for this species in other resources -infected Aotus infulatus check for this species in other resources Monkeys
Leonardo J de Moura Carvalho; Francisco Acácio Alves; Salma Gomes de Oliveira; Rodrigo del Rio do Valle; Andréa A Morais Fernandes; José A Pereira Carneiro Muniz & Claudio T Daniel-Ribeiro

Abstract

Severe anemia is the earliest and a frequently fatal complication of Plasmodium falciparum check for this species in other resources infection. Here we describe Aotus infulatus check for this species in other resources as a primate model suitable to study this malaria complication. Both non-splenectomized and splenectomized monkeys receiving different inocula of P. falciparum FVO strain presented large (> 50%) decreases in hematocrit values during infection. Non-splenectomized animals were able to control parasite growth (parasitemia did not exceed 4%), but they had to be treated because of severe anemia. Three of 4 splenectomized monkeys did not control parasitemia and were treated, but developed severe anemia after treatment when presenting a negative blood film. Destruction of parasitized red blood cells alone cannot account for the degree of anemia. Non-splenectomized monkeys repeatedly infected with homologous parasites became rapidly and progressively resistant to reinfection and to the development of severe anemia. The data presented here point to A. infulatus as a suitable model for studying the pathogenesis of severe malarial infection.

Keywords
malaria - Plasmodium falciparum check for this species in other resources - Aotus infulatus check for this species in other resources - primate model

 
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