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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 6, 2003, pp. 839-841
Bioline Code: oc03168
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 6, 2003, pp. 839-841

 en In Vitro Susceptibility Characteristics of Cryptococcus neoformans check for this species in other resources Varieties from AIDS Patients in Goiânia, Brazil
Orionalda de FL Fernandes; Xisto S Passos; Lúcia KH Souza; André TB Miranda; Carlos Henrique PV Cerqueira & Maria do Rosário R Silva

Abstract

Sixty clinical isolates of Cryptococcus neoformans check for this species in other resources from AIDS from Goiânia, state of Goiás, Brazil, were characterized according to varieties, serotypes and tested for antifungal susceptibility. To differentiate the two varieties was used L-canavanine-glycine-bromothymol blue medium and to separate the serotypes was used slide agglutination test with Crypto Check Iatron. The Minimal Inhibitory Concentration (MIC) of fluconazole, itraconazole, and amphotericin B were determined by the National Committee for Clinical Laboratory Standards macrodilution method. Our results identified 56 isolates as C. neoformans var. neoformans serotype A and 4 isolates as C. neoformans var. gattii serotype B. MIC values for C. neoformans var. gattii were higher than C. neoformans var. neoformans. We verified that none isolate was resistant to itraconazole and to amphotericin B, but one C. neoformans var. neoformans and three C. neoformans var. gattii isolates were resistant to fluconazole. The presence of C. neoformans var. gattii fluconazole resistant indicates the importance of determining not only the variety of C. neoformans infecting the patients but also measuring the MIC of the isolate in order to properly orient treatment.

Keywords
serotypes - antifungal susceptibility - Cryptococcus neoformans check for this species in other resources - Goiânia - Brazil

 
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