Trypanosoma cruzi check for this species in other resources - myocarditis - myosin - autoimmunity - cell adhesion molecules - cell migration"/>
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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 7, 2003, pp. 945-952
Bioline Code: oc03186
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 7, 2003, pp. 945-952

 en Differential Expression of Adhesion Molecules Shaping the T-cell Subset Prevalence during the Early Phase of Autoimmune and Trypanosoma cruzi check for this species in other resources -elicited Myocarditis
Ana Paula MP Marino; Maria Inês P Azevedo & Joseli Lannes-Vieira

Abstract

The participation of cell adhesion molecules (CAMs) in the establishment of autoimmune and infectious myocarditis is an important matter of investigation and may have therapeutic implication. Trypanosoma cruzi check for this species in other resources infection induces a CD8-mediated myocarditis in patients with severe cardiomyopathy and experimental animals. Previously, we have proposed that this predominance of CD8+ T-cells is, at least in part, consequence of the differential expression of CAMs on circulating CD8+ lymphocytes. In the present study we investigated the participation of CAMs in shaping the phenotypic nature of the autoimmune CD4-mediated myosin-induced and the CD8-mediated T. cruzi-elicited myocarditis. We provide evidence that the prevalence of a certain T-cell subset inside the inflamed heart reflects the differential profile of the adhesion molecules VLA-4, LFA-1, and ICAM-1 displayed on a large proportion of this particular T-cell population in peripheral blood during the early phase of inflammation. Further, the expression of VCAM-1, ligand for VLA-4, and ICAM-1, counter-receptor for LFA-1, was up-regulated on vascular endothelium and paralleled the entrance of inflammatory cells into the cardiac tissue. Thus, this up-regulated expression of receptors-counter-receptors that regulate T-cell transmigration through the vascular endothelium may have an important role in the pathogenesis of the early phase of both autoimmune and infectious myocarditis.

Keywords
Trypanosoma cruzi check for this species in other resources - myocarditis - myosin - autoimmunity - cell adhesion molecules - cell migration

 
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