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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 7, 2003, pp. 959-961
Bioline Code: oc03188
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 7, 2003, pp. 959-961

 en Antimicrobial Activity in Vitro of Plumbagin Isolated from Plumbago check for this species in other resources Species
Selma Ribeiro de Paiva; Maria Raquel Figueiredo; Tânia Verônica Aragão & Maria Auxiliadora Coelho Kaplan

Abstract

Plumbagin is a naturally occurring naphthoquinone isolated from roots of Plumbago scandens check for this species in other resources . The plant was collected at the Campus of Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. P. scandens is used as a traditional medicine for the treatment of several diseases. The antimicrobial activity of plumbagin was evaluated using the macrodilution method. The compound exhibited relatively specific activity against bacteria and yeast. The minimum inhibitory concentration test showed the growth inhibiton of Staphylococcus aureus check for this species in other resources at a concentration of 1.56 μg/ml and of Candida albicans check for this species in other resources at a concentration of 0.78 μg/ml. These results suggest the naphthoquinone plumbagin as a promising antimicrobial agent.

Keywords
Plumbago scandens check for this species in other resources - plumbagin - antimicrobial activity

 
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