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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 98, No. 8, 2003, pp. 1093-1095
Bioline Code: oc03213
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 98, No. 8, 2003, pp. 1093-1095

 en SHORT COMMUNICATION - Detection of Pathogenic Bacteria in Skin Lesions of Patients with Chiclero's Ulcer. Reluctant Response to Antimonial Treatment
Angélica Patricia Isaac-Márquez & Claudio Manuel Lezama-Dávila

Abstract

We investigated the bacterial flora present in skin lesions of patients with chiclero's ulcer from the Yucatan peninsula of Mexico using conventional culture methods (11 patients), and an immunocolorimetric detection of pathogenic Streptococcus pyogenes (15 patients). Prevalence of bacteria isolated by culture methods was 90.9% (10/11). We cultured, from chiclero's ulcers (60%), pathogenic bacterial such as Staphylococcus aureus check for this species in other resources (20%), S. pyogenes (1.6%), Pseudomonas aeruginosa check for this species in other resources (1.6%), Morganella morganii check for this species in other resources (1.6%), and opportunist pathogenic bacteria such as Klebsiella check for this species in other resources spp. (20.0%), Enterobacter check for this species in other resources spp. (20%), and Enterococcus check for this species in other resources spp. (20%). We also cultured coagulase-negative staphylococci in 40% (4/10) of the remaining patients. Micrococcus check for this species in other resources spp. and coagulase-negative staphylococci constituted the bacterial genuses more frequently isolated in the normal skin of patients with chiclero's ulcer and healthy individuals used as controls. We also undertook another study to find out the presence of S. pyogenes by an immunocolorimetric assay. This study indicated that 60% (9/15) of the ulcerated lesions, but not normal controls, were contaminated with S. pyogenes. Importantly, individuals with purulent secretion and holding concomitant infections with S. pyogenes, S. aureus, P. aeruginosa, M. morganii, and E. durans took longer to heal Leishmania (L.) mexicana infections treated with antimonial drugs. Our results suggest the need to eliminate bacterial purulent infections, by antibiotic treatment, before starting antimonial administration to patients with chiclero's ulcer.

Keywords
chiclero's ulcer - bacterial flora - antimonial treatment - Mexico

 
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