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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 2, 2004, pp. 227-231
Bioline Code: oc04041
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 2, 2004, pp. 227-231

 en Trypanocidal Activity of Meliaceae and Rutaceae Plant Extracts
Alessandra Regina Pepe Ambrozin; Paulo Cezar Vieira; João Batista Fernandes; Maria Fátima das Graças Fernandes da Silva & Sérgio de Albuquerque

Abstract

The in vitro trypanocidal activity of 22 extracts and 43 fractions of plants belonging to the families Meliaceae and Rutaceae was evaluated. The extracts from leaves of Conchocarphus heterophyllus check for this species in other resources and branches of Trichilia ramalhoi check for this species in other resources were the most active. The trypanocidal activity seems to be increased by fractionation of the extracts. Fractions from C. heterophyllus and Galipea carinata check for this species in other resources were the most active and a 100% lysis of the parasites was observed for five fractions. From one of them were isolated two flavonoids: flavone and 7-methoxyflavone, which showed weak trypanocidal activity. The results obtained from the extracts and fractions revealed that the order Rutales is a promising source for the search of new drugs for Chagas disease. Phytochemical studies with the other active fractions are underway in order to isolate compounds, which could be associated with observed activities.

Keywords
Meliaceae - Rutaceae - Chagas disease - trypanocidal activity

 
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