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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 3, 2004, pp. 281-282
Bioline Code: oc04050
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 3, 2004, pp. 281-282

 en SHORT COMMUNICATION - Prevalence of Human Papillomavirus Type 16 Variants in the Federal District, Central Brazil
Márcio R Cruz; Daniela M Cerqueira; Waldenor B Cruz; Geni NL Camara; Marcelo M Brígido; Evandro O Silva; Luciano GS Carvalho & Cláudia RF Martins

Abstract

We report the prevalence of human papillomavirus type 16 (HPV-16) variants in women with cervical lesions from the Federal District, Central Brazil. We analyzed 34 HPV-16 samples, identifying the sequence variations of E6 and L1 genes and correlating variant frequency with disease status. The most prevalent HPV-16 variant was the European (50%), followed by Asian-American (41.2%), African-1 (5.9%), and African-2 (2.9%). European and non-European variants appeared in equal frequencies among the cytological types of lesions atypical squamous or glandular cells of undetermined significance, cytological alterations suggesting HPV infection, cervical intraepithelial neoplasias, squamous cell carcinoma, and adenocarcinoma.

Keywords
human papillomavirus type 16 - variants - Federal District, Brazil

 
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