search
for
 About Bioline  All Journals  Testimonials  Membership  News  Donations


Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 3, 2004, pp. 283-287
Bioline Code: oc04051
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 3, 2004, pp. 283-287

 en Pulmonary Tuberculosis: Evaluation of Interferon-γ Levels as an Immunological Healing Marker Based on the Response to the Bacillus Calmette-guerin
EP Moura; VPCP Toledo; MHP Oliveira; S Spíndola-de-Miranda; HM Andrade & TMPD Guimarães

Abstract

Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis check for this species in other resources whose interaction with the host may lead to a cell-mediated protective immune response. The presence of interferon-γ (IFN-γ) is related to this response. With the purpose of understanding the immunological mechanisms involved in this protection, the lymphoproliferative response, IFN-γ and other cytokines like interleukin (IL-5, IL-10), and tumor necrosis factor alpha (TNF-α) were evaluated before and after the use of anti-TB drugs on 30 patients with active TB disease, 24 healthy household contacts of active TB patients, with positive purified protein derivative (PPD) skin tests (induration ≥ 10 mm), and 34 asymptomatic individuals with negative PPD skin test results (induration ≤ 5 mm). The positive lymphoproliferative response among peripheral blood mononuclear cells of patients showed high levels of IFN-γ, TNF-α, and IL-10. No significant levels of IL-5 were detected. After treatment with rifampicina, isoniazida, and pirazinamida, only the levels of IFN-γ increased significantly (p < 0.01). These results highlight the need for further evaluation of IFN-γ production as a healing prognostic of patients treated.

Keywords
tuberculosis - interleukin-5 - interleukin-10 - tumor necrosis factor alpha - interferon-g - peripheral blood mononuclear cells

 
© Copyright 2004 - Instituto Oswaldo Cruz - Fiocruz.
Alternative site location: http://memorias.ioc.fiocruz.br

Home Faq Resources Email Bioline
© Bioline International, 1989 - 2017, Site last up-dated on 05-Dec-2017.
Site created and maintained by the Reference Center on Environmental Information, CRIA, Brazil
System hosted by the Internet Data Center of Rede Nacional de Ensino e Pesquisa, RNP, Brazil