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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 3, 2004, pp. 289-294
Bioline Code: oc04052
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 3, 2004, pp. 289-294

 en Leishmania braziliensis: Partial Control of Experimental Infection by Interleukin-12 p40 Deficient Mice
Sebastião Martins de Souza-Neto; Cláudia Martins Carneiro; Leda Quercia Vieira & Luís Carlos Crocco Afonso

Abstract

Resistance to infection by Leishmania major check for this species in other resources has been associated with the development of a Th1 type response that is dependent on the presence of interleukin 12 (IL-12). In this work the involvement of this cytokine in the response to infection by L. braziliensis, a less virulent species in the mouse model, was evaluated. Our results show that while interferon (IFN-γ) deficient (-/-) mice inoculated L. braziliensis develop severe uncontrolled lesions, chronic lesions that remained under control up to 12 weeks of infection were observed in IL-12p40 -/- mice. IL 12p40 -/- mice had fewer parasites in their lesions than IFN-γ-/- mice. Lymph node cells from IL-12p40 -/- were capable of producing low but consistent levels of IFN-γ suggestive of its involvement in parasite control. Furthermore, as opposed to previous reports on L. major-infected animals, no switch to a Th2 response was observed in IL-12p40 -/- infected with L. braziliensis.

Keywords
cutaneous leishmaniasis - Leishmania braziliensis - interleukin 12

 
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