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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 3, 2004, pp. 325-327
Bioline Code: oc04058
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 3, 2004, pp. 325-327

 en Anti-leishmanial Activity of Alkaloidal Extract from Aspidosperma ramiflorum check for this species in other resources
Izabel Cristina Piloto Ferreira; Maria Valdrinez Campana Lonardoni; Gerzia MC Machado; Leonor L Leon; Lucílio Gobbi Filho; Luís Henrique Bissoli Pinto & Arildo José Braz de Oliveira

Abstract

Infections due to protozoa of the genus Leishmania check for this species in other resources are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and cardiac toxicity. Besides, the precise chemical structure and mechanism of action of these drugs are unknown up to date. In order to find new drugs against leishmaniasis, we have been studying extracts of Brazilian trees. In the present study, we have evaluated the effectiveness of an alkaloid extract of Aspidosperma ramiflorum check for this species in other resources Muell. Arg. (Apocynaceae), against the extracellular forms promastigotes of L. (L.) amazonensis and L. (V.) braziliensis. The alkaloid extract of A. ramiflorum was much more effective against L. (L.) amazonensis (LD50 < 47 μg/ml) than L. (V.) braziliensis. Based on these in vitro results against L. (L.) amazonensis new studies should be made to find the compounds with anti-leishmanial activity.

Keywords
Apocynaceae - anti-leishmanial activity - Brazilian trees - monoterpenoid indolic alkaloids - Aspidosperma ramiflorum - Leishmania amazonensis - Leishmania braziliensis

 
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