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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 3, 2004, pp. 329-330
Bioline Code: oc04059
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 3, 2004, pp. 329-330

 en SHORT COMMUNICATION - Effect of Thiadiazine Derivatives on Intracellular Amastigotes of Leishmania amazonensis check for this species in other resources
Lianet Monzote Fidalgo; Ana Margarita Montalvo Álvarez; Lisset Fonseca Geigel; Rolando Pérez Pineiro; Margarita Suárez Navarro & Hortensia Rodríguez Cabrera

Abstract

Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.

Keywords
Leishmania - thiadiazine - amastigotes

 
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