Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 99, No. 3, 2004, pp. 329-330
Bioline Code: oc04059
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 3, 2004, pp. 329-330
© Copyright 2004 - Instituto Oswaldo Cruz - Fiocruz.
SHORT COMMUNICATION - Effect of Thiadiazine Derivatives on Intracellular Amastigotes of Leishmania amazonensis |
Lianet Monzote Fidalgo; Ana Margarita Montalvo Álvarez; Lisset Fonseca Geigel; Rolando Pérez Pineiro; Margarita Suárez Navarro & Hortensia Rodríguez Cabrera
Current therapy for leishmaniasis is not satisfactory. We describe the in vitro antiproliferative effects of new thiadiazine derivatives against Leishmania amazonensis. The compounds were found to be active against the amastigote form of the parasite, inhibiting parasite growing, from 10 to 89%, at a concentration of 100 ng/ml. This activity suggests that thiadiazine derivatives could be considered as potential antileishmanial compounds.
Leishmania - thiadiazine - amastigotes
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