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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 4, 2004, pp. 393-398
Bioline Code: oc04070
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 4, 2004, pp. 393-398

 en Experimental Lagochilascariosis: Histopathological Study of Inflammatory Response to Larval Migration in the Murine Model
Amélia Regina Semerene; Ruy de Souza Lino Junior; Jayrson Araújo Oliveira; Albino Verçosa Magalhães; Mariane Martins Araújo Stefani; Alverne Passos Barbosa & Dulcinéa Maria Barbosa Campos

Abstract

The goal of this study was to investigate the pattern of inflammatory response induced by Lagochilascaris minor check for this species in other resources in murine experimental model. For this purpose 115 mice were given 1000-3000 L. minor infective eggs "per os" and 51 uninfected mice were considered as controls. Four hours post-inoculation (PI), 3rd stage larvae were seen passing through the mucosa of terminal ends of small intestine. Six hours PI larvae were observed as an embolus inside the portal vein and also migrating through the liver parenchyma. During the first 24 h larvae-containing eggs of L. minor were observed in the lumen of intestinal tract. Two days PI larvae were seen migrating through lung parenchyma associated with an initial neutrophilic perivasculitis. From the 13th day of this experimental study, L. minor larvae were found mainly in skeletal muscles, in the center of granulomas. Concentric fibrosis with mixed inflammatory infiltrate involved the larvae after the 47th day PI, persistently. This experimental murine study with L. minor indicated that the 3rd stage larvae penetrated via ileum-cecal mucosa reaching the liver and probably other tissues through the hematogenic via. Throughout its pathway the larvae induced a granulomatous reaction, with abundant polimorphonuclear cells.

Keywords
Lagochilascaris minor - experimental infection - inflammatory response

 
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