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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. s1, 2004, pp. 121-126
Bioline Code: oc04099
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. s1, 2004, pp. 121-126

 en Clinical and Immunological Consequences of Human T Cell Leukemia Virus Type-I and Schistosoma mansoni check for this species in other resources Co-infection
Silvane Braga Santos; Aurélia Fonseca Porto; André Luiz Muniz; Amélia Ribeiro de Jesus & Edgar M Carvalho

Abstract

Human T cell leukemia virus type-I (HTLV-I) infection is associated with spontaneous T cell activation and uncontrolled lymphocyte proliferation. An exacerbated type-1 immune response with production of pro-inflammatory cytokines (interferon-γ and tumor necrosis factor-α) is significantly higher in patients with myelopathy associated to HTLV-I than in HTLV-I asymptomatic carriers. In contrast with HTLV-I, a chronic Schistosoma mansoni check for this species in other resources infection is associated with a type-2 immune response with high levels of interleukin (IL-4, IL-5, and IL-10) and low levels of IFN-γ. In this study, clinical and immunological consequences of the HTLV-I and S. mansoni infection were evaluated. The immune response in patients with schistosomiasis co-infected with HTLV-I showed low levels of IL-5 (p < 0.05) in peripheral blood mononuclear cells cultures stimulated with S. mansoni antigen (SWAP) and decreased SWAP-specific IgE levels when compared with patients with only schistosomiasis (p < 0.05). Liver fibrosis was mild in all HTLV-I co-infected patients. Immunological response was also compared in individuals who had only HTLV-I infection with those who were co-infected with HTLV-I and helminths (S. mansoni and Strongyloides stercoralis check for this species in other resources ). In patients HTLV-I positive co-infected with helminths the IFN-γ levels were lower than in individuals who had only HTLV-I. Moreover, there were fewer cells expressing IFN-γ and more cells expressing IL-10 in individuals co-infected with HTLV-I and helminths. These dates indicate that HTLV-I infection decrease type 2-response and IgE synthesis and are inversely associated with the development of liver fibrosis. Moreover, helminths may protect HTLV-I infected patients to produce large quantities of pro-inflammatory cytokines such as IFN-γ.

Keywords
human T cell leukemia virus type-1 - Schistoma mansoni - co-infection

 
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