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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 6, 2004, pp. 559-562
Bioline Code: oc04118
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 6, 2004, pp. 559-562

 en Association of Human Leukocyte Antigen DQ1 and Dengue Fever in a White Southern Brazilian Population
José Roberto Polizel; Danilo Bueno; Jeane Eliete L Visentainer; Ana Maria Sell; Sueli Donizete Borelli; Luiza Tamie Tsuneto; Marcia Machado O Dalalio; Maria Teresa M Coimbra & Ricardo Alberto Moliterno

Abstract

Dengue is an infectious disease of viral etiology transmitted by the mosquitoes Aedes aegypti check for this species in other resources , A. albopictus, and A. scutellaris. It can develop either as a benign form or as a severe hemorrhagic form. Previous work showed an association of the hemorrhagic form with human leukocyte antigens (HLA), suggesting a role of genetic factors in disease susceptibility. Nevertheless, data on HLA association with the classical form of the disease is scarce in literature. Sixty-four patients and 667 normal individuals, living in the state of Paraná, Southern Brazil, were used as test and control group, respectively. The patients developed the disease during a virus 1 dengue outbreak either in Maringá city in 1995 (47) or in Paranavaí city in 1999 (17). The diagnostic was confirmed through serology and/or viral culture. HLA class I and II typing was performed by the classical microlynfocitotoxicity test using monoclonal antisera and fluorobeads. Qui-square statistical analysis confirmed a positive association with HLA-DQ1 (76.6% vs 57.7%; p = 0.005243; pc = 0.026215). HLA-DR1 also presented an increased frequency in the test group, not statistically significant after p correction though (32.8% vs 15.9%; p = 0.005729; pc = 0.080206). In conclusion, genetic factors may play a role on the susceptibility to the classical dengue, virus 1, in the Brazilian population. Further independent studies should be performed in the Brazilian population to confirm these preliminary data.

Keywords
human leukocyte antigens - dengue fever - Brazil

 
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