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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 99, No. 6, 2004, pp. 651-656
Bioline Code: oc04135
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 99, No. 6, 2004, pp. 651-656

 en Cytotoxicity of Three New Triazolo-pyrimidine Derivatives against the Plant Trypanosomatid: Phytomonas check for this species in other resources sp. Isolated from Euphorbia characias check for this species in other resources
Rosa Magán; Clotilde Marín; Juan M Salas; Mario Barrera-Pérez; Maria J Rosales & Manuel Sánchez-Moreno

Abstract

There is no effective chemotherapy against diseases caused by Phytomonas check for this species in other resources sp., a plant trypanosomatid responsible for economic losses in major crops. We tested three triazolo-pyrimidine complexes [two with Pt(II), and another with Ru(III)] against promastigotes of Phytomonas sp. isolated from Euphorbia characias check for this species in other resources . The incorporation of radiolabelled precursors, ultrastructural alterations and changes in the pattern of metabolite excretion were examined. Different degrees of toxicity were found for each complex: the platinun compound showed an inhibition effect on nucleic acid synthesis, provoking alterations on the levels of mitochondria, nucleus and glycosomes. These results, together with others reported previously in our laboratory about the activity of pyrimidine derivatives, reflect the potential of these compounds as agents in the treatment of Phytomonas sp.

Keywords
Phytomonas sp. - triazolo-pyrimidine complexes - chemotherapeutic agents

 
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