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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. s1, 2005, pp. 93-96
Bioline Code: oc05032
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. s1, 2005, pp. 93-96

 en CC-chemokine receptors: a potential therapeutic target for Trypanosoma cruzi check for this species in other resources -elicited myocarditis
APMP Marino; AA Silva; PVA Santos; LMO Pinto; RT Gazinelli; MM Teixeira & J Lannes-Vieira

Abstract

The comprehension of the pathogenesis of Trypanosoma cruzi check for this species in other resources -elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1α, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines and their receptors in the pathogenesis of T. cruzi-elicited myocarditis. Herein, we discuss our recent results using a CC-chemokine receptor inhibitor (Met-RANTES), showing the participation of CC-chemokines in T. cruzi infection and unraveling CC-chemokine receptors as an attractive therapeutic target for further evaluation in Chagas disease.

Keywords
Trypanosoma cruzi - myocarditis - CC-chemokines - CC-chemokine receptors - Met-RANTES

 
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