Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
Vol. 100, No. s1, 2005, pp. 105-106
Bioline Code: oc05034
Full paper language: English
Document type: Research Article
Document available free of charge
Memórias do Instituto Oswaldo Cruz, Vol. 100, No. s1, 2005, pp. 105-106
© Copyright 2005 - Instituto Oswaldo Cruz - Fiocruz.
Hemopressin: a novel bioactive peptide derived from the α1-chain of hemoglobin|
Camila Squarzoni Dale; Rosana de Lima Pagano & Vanessa Rioli
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the a1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.
antinociception - blood pressure - hemopressin
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