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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. s1, 2005, pp. 161-165
Bioline Code: oc05044
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. s1, 2005, pp. 161-165

 en Local anaesthetic medication for the treatment of asthma
Rodrigo A Siqueira; Jorge CS Costa; Renato SB Cordeiro; Magda F Serra; Patrícia MR & Silva, Marco A Martins

Abstract

It is presumed that drugs able to prevent bronchial spasm and/or inflammation may have therapeutic potential to control asthma symptoms. The local anaesthetic lidocaine has recently received increased attention as an alternative form of treatment for asthmatic patients. This paper reviews the major findings on the topic and summarizes the putative mechanisms underlying the airway effects of local anaesthetic agents. We think that lidocaine extends the spectrum of options in asthma therapy, probably by counteracting both spasmogenic and inflammatory stimuli in the bronchial airways. The possibility of development of new anti-asthma compounds based on the synthesis of lidocaine derivatives is also on the horizon.

Keywords
local anaesthetic - lidocaine - inflammation - asthma

 
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