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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 2, 2005, pp. 111-116
Bioline Code: oc05057
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 2, 2005, pp. 111-116

 en Blood transfusion and iatrogenic risks in Mexico city. Anti- Trypanosoma cruzi check for this species in other resources seroprevalence in 43,048 blood donors, evaluation of parasitemia, and electrocardiogram findings in seropositive
Nidia Hernández-Becerril; Ana Maria Mejía; Martha Alicia Ballinas-Verdugo; Verónica Garza-Murillo; Elsa Manilla-Toquero; Ruth López; Sergio Trevethan; Manuel Cardenas; Pedro Antonio Reyes; Kenji Hirayama & Victor Manuel Monteón


Iatrogenous transmission of Trypanosoma cruzi check for this species in other resources by blood transfusion was suggested as a potential risk by Pellegrino (1949). Seropositive blood donors in Mexico were first reported in 1978, however, limited information is available due to small sampling, the use of heterogeneous serologic assays, and geographically limited studies. A wide survey carried out in 18 out of the 32 states of Mexico, showed a national mean of 1.6% seropositive among 64,969 donors, ranging from 0.2 to 2.8%.

In the present study, we have screened 43,048 voluntary blood donors in a period of five years at the Instituto Nacional de Cardiología I. Chávez, a concentration hospital located in Mexico city which serves mainly the metropolitan area and accepts from all over the country. Standardized ELISA and IIF were used to identify seropositive individuals in addition to hemoculture, PCR and standard 12 lead ECG tests that were applied to a group of seropositive patients (29/161). The result showed a seropositivity of 0.37% (161/43,048). From the group of seropositive individuals 40% (12/29) were potential carriers of T. cruzi at the donation time and 5/29 had subclinical ECG abnormalities. Parasitological tests performed in 70 erythrocyte and platelet fractions from seropositive units (70/161) showed negative results. Our findings strongly support T. cruzi screening in the transfusion medicine practice and identify subclinical heart disease among seropositive blood donors.

Trypanosoma cruzi - Chagas disease - blood bank - seroprevalence - Mexico

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