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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 2, 2005, pp. 205-211
Bioline Code: oc05071
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 2, 2005, pp. 205-211

 en Sativa check for this species in other resources seeds against Schistosoma mansoni check for this species in other resources different stages
Azza M Mohamed; Nadia M Metwally & Sohair S Mahmoud

Abstract

The schistosomicidal properties of Nigella sativa check for this species in other resources seeds were tested in vitro against Schistosoma mansoni check for this species in other resources miracidia, cercariae, and adult worms. Results indicate its strong biocidal effects against all stages of the parasite and also showed an inhibitory effect on egg-laying of adult female worms. In the present work we also studied the effects of crushed seeds on some antioxidant enzymes; which have a role in protection of adult worms against host oxidant killing; as well as some enzymes of glucose metabolism; which have a crucial role in the survival of adult worms inside their hosts. The data revealed that the used drug induce an oxidative stress against adult worms which indicated by a decrease in the activities of both antioxidant enzymes, superoxide dismutase, glutathione peroxidase, and glutathione reductase and enzymes of glucose metabolism, hexokinase and glucose-6-phosphate dehydrogenase. Disturbing of such enzymes of adult worms using N. sativa seeds could in turn render the parasite vulnerable to damage by the host and may play a role in the antischistosomal potency of the used drug.

Keywords
Nigella sativa - Schistosoma mansoni - miracidia - cercariae - adult worms - antioxidant enzymes - glucose metabolism

 
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