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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060 EISSN: 1678-8060
Vol. 100, No. 3, 2005, pp. 303-307
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Bioline Code: oc05088
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 3, 2005, pp. 303-307
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Evaluation of five screening tests licensed in Argentina for detection of hepatitis C virus antibodies
Viviana Ré; Sandra Gallego; Elena Treviño; Gabriela Barbás; Claudia Domínguez; Osvaldo Elbarcha; Héctor Bepre & Marta Contigiani
Abstract
This study was
conducted to compare among the most recent generation of five screening
tests licensed in Argentina, in order to evaluate which of the tests has
the best sensitivity for detection of antibodies against hepatitis C virus
(HCV). The tests
analyzed were: Detect-HCVTM (3.0) Biochem ImmunoSystems, Canada;
Hepatitis C EIA Wiener Lab., Argentina; Equipar HCV Ab, Italy; Murex HCV
4.0, UK and Serodia-HCV particles agglutination test, Japan. The
results obtained showed high discrepancy between the different kits used
and show that some of the tests assessed have a low sensitivity for anti-HCV
detection in both chronic infections and early seroconversion, and indicate
that among the commercially available kits in Argentina, Murex HCV 4.0
(UK) and Serodia-HCV particles agglutination test (Japan) have the best
sensitivity for HCV screening. Although
the sensitivity of the assays is the first parameter to be considered for
blood screening, more studies should be carried out to assess the specificity
of such assays.
Keywords
hepatitis C virus (HCV) - HCV screening test - sensitivity
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© Copyright 2005 Instituto Oswaldo Cruz - Fiocruz Alternative site location: http://memorias.ioc.fiocruz.br
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