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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 4, 2005, pp. 391-395
Bioline Code: oc05102
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 4, 2005, pp. 391-395

 en A mucin like gene different from the previously reported members of the mucin like gene families is transcribed in Trypanosoma cruzi check for this species in other resources but not in Trypanosoma rangeli check for this species in other resources
Teresa Abate; Mónica Rincón; Zoraida Díaz-Bello; Lilian Spencer & Alexis Rodríguez-Acosta

Abstract

Trypanosoma cruzi check for this species in other resources expresses mucin like glycoproteins encoded by a complex multigene family. In this work, we report the transcription in T. cruzi but not in T. rangeli of a mucin type gene automatically annotated by the T. cruzi genome project. The gene showed no nucleotide similarities with the previously reported T. cruzi mucin like genes, although the computational analysis of the deduced protein showed that it has the characteristic features of mucins: a signal peptide sequence, O-glycosylation sites, and glycosylphosphatidylinositol (GPI) anchor sequence. The presence in this gene of N- terminal and C- terminal coding sequences common to other annotated mucin like genes suggests the existence of a new mucin like gene family.

Keywords
mucin like gene - Trypanosoma cruzi - Trypanosoma rangeli

 
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