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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 4, 2005, pp. 403-405
Bioline Code: oc05104
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 4, 2005, pp. 403-405

 en SHORT COMMUNICATION - Suppression of Brugia malayi check for this species in other resources (sub-periodic) larval development in Aedes aegypti check for this species in other resources (Liverpool strain) fed on blood of animals immunized with microfilariae
K. Athisaya Mary; K. P. Paily & S. Hoti

Abstract

Preliminary studies were carried out to investigate the role of filarial specific antibodies, raised in an animal model against the filarial parasite, Brugia malayi check for this species in other resources (sub-periodic), in blocking their early development in an experimental mosquito host, Aedes aegypti check for this species in other resources (Liverpool strain). In order to generate filarial specific antibodies, Mongolian gerbils, Meriones unguiculatus, were immunized either with live microfilariae (mf) of B. malayi or their homogenate. Mf were harvested from the peritoneal cavity of Mongolian gerbils with patent infection of B. malayi and fed to A. aegypti along with the blood from immunized animals. Development of the parasite in infected mosquitoes was monitored until they reached infective stage larvae (L3). Fewer number of parasites developed to first stage (L1) and subsequently to L2 and L3 in mosquitoes fed with blood of immunized animals, when compared to those fed with blood of control animals. The results thus indicated that filarial parasite specific antibodies present in the blood of the immunized animals resulted in the reduction of number of larvae of B. malayi developing in the mosquito host.

Keywords
microfilariae - Mongolian gerbil - antibodies - mosquito host - larval development

 
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