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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 7, 2005, pp. 771-778
Bioline Code: oc05162
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 7, 2005, pp. 771-778

 en Efficacy of Citrus reticulata and Mirazid in treatment of Schistosoma mansoni check for this species in other resources
Manal A Hamed & Mona H Hetta

Abstract

This work has been carried out to investigate the effect of Schistosoma mansoni check for this species in other resources infection on mice livers after treatment with the ethanolic extract of Citrus reticulata check for this species in other resources root or the oleo-resin extract from Myrrh of Commiphora molmol check for this species in other resources tree (Mirazid), as a new antishistosomal drug. Marker enzymes for different cell organelles were measured; succinate dehydrogenase (SDH); lactate dehydrogenase (LDH) and its isoenzymes; glucose-6-phosphatase (G-6-Pase); acid phosphatase (AP) and 5'- nucleotidase. Liver function enzymes; aspartate aminotransferase (AST); alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also estimated. Parasitological studies through ova count and worm burden will also be taken into consideration. The results showed a marked reduction in SDH, LDH, AST, and ALT enzyme activities and a significant increase in G-6-Pase, AP, 5'- nucleotidase, and ALP after S. mansoni infection. A noticeable alteration in LDH subunits were also noticed. Treatment with C. reticulata or Mirazid improved all the previous enzyme activities with a noticeable reduction in ova count and worm burden.

Keywords
Citrus reticulata - Mirazid - schistosomiasis - enzymes, worm burden - ova count

 
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