This work has been carried out to investigate the effect of Schistosoma mansoni
infection on mice livers after treatment with the ethanolic extract of Citrus reticulata
root or the oleo-resin extract from Myrrh of Commiphora molmol
tree (Mirazid), as a new antishistosomal drug. Marker enzymes for different cell organelles were measured; succinate dehydrogenase (SDH); lactate dehydrogenase (LDH) and its isoenzymes; glucose-6-phosphatase (G-6-Pase); acid phosphatase (AP) and 5'- nucleotidase. Liver function enzymes; aspartate aminotransferase (AST); alanine aminotransferase (ALT), and alkaline phosphatase (ALP) were also estimated. Parasitological studies through ova count and worm burden will also be taken into consideration. The results showed a marked reduction in SDH, LDH, AST, and ALT enzyme activities and a significant increase in G-6-Pase, AP, 5'- nucleotidase, and ALP after S. mansoni
infection. A noticeable alteration in LDH subunits were also noticed. Treatment with C. reticulata
or Mirazid improved all the previous enzyme activities with a noticeable reduction in ova count and worm burden.