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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 7, 2005, pp. 783-787
Bioline Code: oc05164
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 7, 2005, pp. 783-787

 en Antileishmanial and trypanocidal activity of Brazilian Cerrado plants
Mariana Laundry de Mesquita; Julie Desrivot; Christian Bories; Alain Fournet; José Elias de Paula; Philippe Grellier & Laila Salmen Espindola

Abstract

The side effects and the emerging resistance to the available drugs against leishmaniasis and trypanosomiasis led to the urgent need for new therapeutic agents against these diseases. Thirty one extracts of thirteen medicinal plants from the Brazilian Cerrado were therefore evaluated in vitro for their antiprotozoal activity against promastigotes of Leishmania donovani check for this species in other resources , and amastigotes of Trypanosoma cruzi check for this species in other resources . Among the selected plants, Casearia sylvestris check for this species in other resources var. lingua was the most active against both L. donovani and T. cruzi. Fifteen extracts were active against promastigotes of L. donovani with concentrations inhibiting 50% of parasite growth (IC50) between 0.1-10 μg/ml, particularly those of Annona crassiflora check for this species in other resources (Annonaceae), Himatanthus obovatus check for this species in other resources (Apocynaceae), Guarea kunthiana check for this species in other resources (Meliaceae), Cupania vernalis check for this species in other resources (Sapindaceae), and Serjania lethalis check for this species in other resources (Sapindaceae). With regard to amastigotes of T. cruzi, extracts of A. crassiflora, Duguetia furfuracea check for this species in other resources (Annonaceae), and C. sylvestris var. lingua were active with IC50 values between 0.3-10 μg/ml. Bioassay fractionations of the more active extracts are under progress to identify the active antiparasite compounds.

Keywords
Brazilian Cerrado plants - leishmaniasis - Chagas disease - Leishmania donovani - Trypanosoma cruzi - Brazil

 
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