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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 8, 2005, pp. 883-887
Bioline Code: oc05178
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 8, 2005, pp. 883-887

 en Evaluation of the natural killer cytotoxicity and the levels of cytokines in rats with type I diabetes mellitus
Isil Fidan; Sevgi Yüksel; Ayse Kalkanci; Turgut Imir & Semra Kustimur

Abstract

Type I diabetes mellitus (insulin-dependent DM = IDDM) is a chronic disease characterized by specific destruction of pancreatic β cells, resulting in an absolute lack of insulin. Immune mechanisms, genetic susceptibility, and environmental factors are all implicated in the pathogenesis of Type 1 diabetes. This study was aimed at determining the efficiency of cytokines, natural killer (NK) cells in the pathophysiology of IDDM. Therefore, we evaluated the plasma levels of cytokines by specific enzyme-linked immunosorbent assay (ELISA) and the cytotoxicity activity of NK cells by anti-candididal index in rats with type I diabetes. We found that the cytotoxicity activity of NK cells in IDDM groups significantly decreased compared to the control groups. The levels of interferon-γ (IFN-γ) in IDDM groups were slightly higher than in healthy controls. These results indicate that the changes of TH1 type cytokines such as IFN-γ and NK cell activity can play a role in the etiology of IDDM. The data may provide new strategies for the treatment of IDDM.

Keywords
Type 1 diabetes mellitus - cytokines - natural killer cells

 
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