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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 100, No. 8, 2005, pp. 889-892
Bioline Code: oc05179
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 100, No. 8, 2005, pp. 889-892

 en Studies in a co-infection murine model of Plasmodium chabaudi chabaudi check for this species in other resources and Leishmania infantum check for this species in other resources : interferon-γ and interleukin-4 mRNA expression
Cláudia S Marques; Nuno Rolão; Sónia Centeno-Lima; Hélder Lousada; Carla Maia; Lenea Campino; Virgílio E do Rosário & Henrique Silveira

Abstract

This work aimed to study the T helper type 1/2 (Th1/Th2) cytokine profile in a co-infection murine model of Plasmodium chabaudi chabaudi check for this species in other resources and Leishmania infantum check for this species in other resources . Expression of interferon-gamma (IFN-γ) and interleukin-4 (IL-4) was analyzed, in spleen and liver of C57BL/6 mice, by reverse transcriptase-polymerase chain reaction. High levels of IFN-γ expression did not prevent the progression of Leishmania in co-infected mice and Leishmania infection did not interfere with the Th1/Th2 switch necessary for Plasmodium control. The presence of IL-4 at day 28 in co-infected mice, essential for Plasmodium elimination, was probably a key factor on the exacerbation of the Leishmania infection.

Keywords
co-infection - Plasmodium - Leishmania

 
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