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Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome Marize Pereira Miagostovich; Flávia Barreto dos Santos; Túlio Machado Fumian; Flávia Ramos Guimarães; Eliane Veiga da Costa; Fernando Neto Tavares; Janice Oliveira Coelho & Rita Maria Ribeiro Nogueira Abstract We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported. Keywords dengue virus type 3 - complete genome - Brazil

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