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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 3, 2006, pp. 307-313
Bioline Code: oc06055
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 3, 2006, pp. 307-313

 en Complete genetic characterization of a Brazilian dengue virus type 3 strain isolated from a fatal outcome
Marize Pereira Miagostovich; Flávia Barreto dos Santos; Túlio Machado Fumian; Flávia Ramos Guimarães; Eliane Veiga da Costa; Fernando Neto Tavares; Janice Oliveira Coelho & Rita Maria Ribeiro Nogueira

Abstract

We have determined the complete nucleotide and the deduced amino acid sequences of Brazilian dengue virus type 3 (DENV-3) from a dengue case with fatal outcome, which occurred during an epidemic in the state of Rio de Janeiro, Brazil, in 2002. This constitutes the first complete genetic characterization of a Brazilian DENV-3 strain since its introduction into the country in 2001. DENV-3 was responsible for the most severe dengue epidemic in the state, based on the highest number of reported cases and on the severity of clinical manifestations and deaths reported.

Keywords
dengue virus type 3 - complete genome - Brazil

 
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