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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 3, 2006, pp. 331-334
Bioline Code: oc06059
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 3, 2006, pp. 331-334

 en Virulence attenuation and phenotypic variation of Paracoccidioides brasiliensis check for this species in other resources isolates obtained from armadillos and patients
SAG Macoris; MF Sugizaki; MTS Peraçoli; SMG Bosco; F Hebeler-Barbosa; LB Simões; RC Theodoro; LA Trinca & E Bagagli

Abstract

Paracoccidioides brasiliensis check for this species in other resources is the etiological agent of paracoccidioidomycosis, the most important systemic mycosis in Latin America. The virulence profiles of five isolates of P. brasiliensis were studied in two different moments and correlated with some colonial phenotypic aspects. We observed a significant decrease in the virulence and an intense phenotypic variation in the mycelial colony. The recognition of all ranges of phenotypic and virulence variation of P. brasiliensis, as well as its physiological and genetic basis, will be important for a better comprehension of its pathogenic and epidemiological features.

Keywords
Paracoccidioides brasiliensis - virulence - hamster - Dasypus novemcinctus

 
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