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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 3, 2006, pp. 341-344
Bioline Code: oc06062
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 3, 2006, pp. 341-344

 en Susceptibility of Colombian Plasmodium falciparum check for this species in other resources isolates to 4-aminoquinolines and the definition of amodiaquine resistance in vitro
Diego F Echeverry; Claribel Murillo; Piedad Restrepo P & Lyda Osorio

Abstract

There are wide variations in the threshold used to define in vitro resistance of Plasmodium falciparum check for this species in other resources to amodiaquine (AQ), probably due to differences in methodology and interpretation. In vitro susceptibility data of Colombian P. falciparum strains to AQ and N-desethylamodiaquine is used to illustrate the need to standardized methodologies and compare inhibitory concentrations, instead of resistant/susceptible phenotypes, when studying the mechanisms of resistance to AQ and monitoring drug susceptibility trends in the field.

Keywords
chloroquine - amodiaquine - N-desethylamodiaquine - in vitro tests

 
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