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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 7, 2006, pp. 733-739
Bioline Code: oc06123
Full paper language: English
Document type: Research Article
Document available free of charge

Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 7, 2006, pp. 733-739

 en Clinical forms of Trypanosoma cruzi check for this species in other resources infected individuals in the chronic phase of Chagas disease in Puebla, Mexico
María del Carmen Sánchez-Guillén; Aurelio López-Colombo; Guillermo Ordóñez-Toquero; Isidoro Gomez-Albino; Judith Ramos-Jimenez; Enrique Torres-Rasgado; Hilda Salgado-Rosas; Mónica Romero-Díaz; Patricia Pulido-Pérez & Ricardo Pérez-Fuentes

Abstract

In Mexico, despite the relatively high seroprevalence of Trypanosoma cruzi check for this species in other resources infection in humans in some areas, reported morbidity of Chagas disease is not clear. We determined clinical stage in 71 individuals seropositive to T. cruzi in the state of Puebla, Mexico, an area endemic for Chagas disease with a reported seroprevalence of 7.7%. Diagnosis of Chagas disease was made by two standardized serological tests (ELISA, IHA). Individuals were stratified according to clinical studies. All patients were submitted to EKG, barium swallow, and barium enema. Groups were identified as indeterminate form (IF) asymptomatic individuals without evidence of abnormalities (n = 34 cases); those with gastrointestinal alterations (12 patients) including symptoms of abnormal relaxation of the lower esophageal sphincter and absent peristalsis in the esophageal body, grade I megaesophagus, and/or megacolon; patients with clinical manifestations and documented changes of chronic Chagas heart disease who were subdivided as follows: mild (8 patients) - mild electrocardiographic changes of ventricular repolarization, sinus bradychardia); moderate (6 patients) - left bundle branch block, right bundle branch block associated with left anterior fascicular block); severe (8 patients) - signs of cardiomegaly, dilated cardiomyopathy); and the associated form (3 cases) that included presence of both cardiomyopathy and megaesophagus. These data highlight the importance of accurate evaluation of the prevalence and clinical course of Chagas disease in endemic and non-endemic areas of Mexico.

Keywords
clinical forms - Chagas disease - seropositive - Trypanosoma cruzi - cardiomyopathy - indeterminate form

 
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