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Memórias do Instituto Oswaldo Cruz
Fundação Oswaldo Cruz, Fiocruz
ISSN: 1678-8060
EISSN: 1678-8060
Vol. 101, No. 7, 2006, pp. 783-785
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Bioline Code: oc06131
Full paper language: English
Document type: Research Article
Document available free of charge
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Memórias do Instituto Oswaldo Cruz, Vol. 101, No. 7, 2006, pp. 783-785
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In vitro inhibition of acetylcholinesterase by crude plant extracts from Colombian flora
Jaime Niño; Jimmy A Hernández; Yaned M Correa & Oscar M Mosquera
Abstract
The methanol extracts from five different plant families (Asteraceae, Euphorbiaceae, Melastomataceae, Rubiaceae, and Solanaceae) collected at Regional Natural Park Ucumarí (Colombia), were screened for their acetylcholinesterase inhibitory activity through the modified Ellman's spectrophotometric method. The best inhibitory activities on this study were shown by the extracts of Solanum leucocarpum Dunal (IC50 = 204.59 mg/l) and Witheringia coccoloboides (Damm) (IC50 = 220.68 mg/l), both plants belonging to the Solanaceae family.
Keywords
acetylcholinesterase (AChE) inhibitors - Asteraceae - Euphorbiaceae - Melastomataceae - Rubiaceae - Solanaceae
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